Active Ingredients: Azithromycin
Its activity in vitro was shown to be slightly lower than that of azithromycin. It was found that macrolide resistance mutations resulting in treatment failures can be rapidly selected during treatment with josamycin, with a mutation selection rate of 6.
Nevertheless, the macrolide resistance selection pressure is still considerable in Russia, particularly because josamycin and azithromycin 1 g single oral dose are widely used as first-line treatments for C.
Data regarding the prevalence of possible fluoroquinolone resistance-associated mutations in Europe remain very limited. However, a majority of this increase was due to the S 83 N mutation that might not result in significantly elevated MICs of moxifloxacin Jensen et al, unpublished.
In addition to nonsynonymous mutations at S 83 and D 87 80 and 84 in E. However, also a ParC S 84 P mutation was found in one sample from Moscow and this mutation has been previously shown to cause resistance to fluoroquinolones in a clinical M.
The recommended second-line treatment for M. Given the suboptimal activity of ofloxacin and levofloxacin against M.
However, the possible resistance to fluoroquinolones was higher than the resistance to macrolides, which is rare internationally. Multidrug resistance in M.
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