Active Ingredients: Azithromycin
In adults, no studies compared dosages by weight. Clinical cure rates were significantly different for the different azithromycin regimens, with differences that resembled those for bacterial cure rate.
Streptococcus pyogenes group A streptococcus is the most common bacterial cause of tonsillopharyngitis requiring treatment with antibiotics. Penicillin has been the recommended drug of choice for the treatment of GAS tonsillopharyngitis since the early 1950 s.
Guidelines published by the Infectious Diseases Society of America recommend erythromycin as treatment for patients who have allergic reactions to penicillin.
Unfortunately, an estimated one-third of patients do not complete therapy with erythromycin because of drug-induced adverse events. The need for multiple daily doses and 10-day treatment regimens also compromises the efficacy of erythromycin therapy.
Gastrointestinal adverse effects are frequent with erythromycin, and they limit its usefulness.
Because of the significant compliance barriers associated with erythromycin, azithromycin—with its convenient once-daily dosing for 3 or 5 days and its lower risk of gastrointestinal adverse events—has become a frequent choice for the treatment of GAS tonsillopharyngitis.
In the United States, a 5-day regimen of azithromycin is approved for treatment of GAS tonsillopharyngitis in adults; outside the United States, a 3-day regimen is approved.
This study uses meta-analytic techniques to evaluate published, randomized, controlled trials involving GAS tonsillopharyngitis to determine the optimal treatment regimen for azithromycin.
Methods Randomized, controlled trials of azithromycin and a 10-day course of comparator antibiotic for the treatment of GAS tonsillopharyngitis in children and adults were identified from searches of the MEDLINE database which contains citations from 1966 through and the Embase database which contains citations from 1970 through.
Abstracts from meetings of the Interscience Conference on Antimicrobial Agents and Chemotherapy, the Infectious Diseases Society of America, and the Society for Pediatric Research were searched to identify relevant trials that had not been published.
The quality of the included trials was assessed using the Jadad scale. The scale assigns scores from 0 lowest-quality trial to 5 highest-quality trial on the basis of the following criteria: random allocation of treatment and specification of the appropriate method, such as a random-number table, in the text of the trial 2 points; double-blind trial design 2 points; and a complete accounting and description of study withdrawals 1 point The primary outcome of interest was bacteriological cure, defined as the failure to isolate GAS from cultures of throat swab samples obtained after completion of the antibiotic course.
What is the recommended dosage for Azithromycin?
One packet should be enough for your symptoms to clear. Please check with your doctor.
To ensure that the chlamydia infection is cured, patients and their treated partners are advised not to have sex for a week.