Active Ingredients: Azithromycin
Human studies addressing gestational use of azithromycin have primarily focused on antibiotic efficacy rather than fetal safety.
Our primary objective was to evaluate the possibility of teratogenic risk following gestational exposure to azithromycin.
Methods There were 3 groups of pregnant women enrolled in our study: 1 women who took azithromycin. They were matched for gestational age at time of call, maternal age, cigarette and alcohol consumption.
Rates of major malformations and other endpoints of interest were compared among the three groups.
Results Pregnancy outcome of 123 women in each group was ascertained. There were no statistically significant differences among the three groups in the rates of major malformations; 3.
In the azithromycin group, 88 71. Our data adds to previous research showing that macrolide antibiotics, as a group, are generally safe in pregnancy and provides an evidence-based option for health professionals caring for populations with chlamydia.
Structural modification resulting from substitution of a nitrogen atom on the lactone ring with a methyl group, protects azithromycin from breakdown by gastric acidity and thereby increases its elimination half-life, making it possible for single dose therapy.
Its unique pharmacokinetic properties offer additional clinical advantages that include a substantial reduction of gastrointestinal side effects and increased patient compliance due to more convenient dosing regimens.
Its main indications for use include treatment of mild to moderate infections of the upper and lower respiratory tract, as well as skin infections.
As well, its anti-inflammatory role in cystic fibrosis was also established. Recently, a large study examining treatment of trachomas almost 1000 people was published, that documented that the prevalence and intensity of infection fell dramatically and remained low for two years after one treatment.
Animal reproductive studies found no evidence of impaired fertility or harm to the fetus following azithromycin exposure.Blood samples were obtained from the in groups the experiment and all animals were.
Only limited information on the effects of azithromycin use during human pregnancy is available.