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Kaplan et al. We were able to document the same association of younger age with isolation of non-susceptible isolates but this study was not designed to collect information regarding day-care attendance or prior antibiotic therapy.
With the advent of penicillin resistance in S. Guidelines by this agency base susceptibility of pneumococci to cefpodoxime, cefaclor, cefixime, loracarbef and cefprozil on susceptibility to penicillin.
Thornsberry in 1993 and Doern in 1998 reported that penicillin susceptibility is not a consistent predictor of cephalosporin susceptibility.
The lack of an official breakpoint precludes the ability to quantify the magnitude of this error but it remains a provocative explanation of reported clinical failures in the treatment of otitis media with these agents.
For antibiotics, pharmacodynamics describes the relationship between drug concentration and its ability to kill or inhibit the growth of microorganisms.
For decades, many clinicians have applied pharmacodynamic principles to explain clinical efficacy. Animal models of infection and human clinical outcome data have demonstrated that antibiotic concentrations do not have to exceed the MIC for the entire dosing interval to maximize antibacterial effect.
In animals infected with S.