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Order Zithromax. Purchase Zithromax Online. Zithromax Medication. Here, we present a preliminary investigation of the ability of Raman spectroscopy to quantify mixtures of four drugs; acetaminophen, azithromycin, epinephrine, and lidocaine, with their primary degradation products.
The Raman spectra for the mixtures were replicated by adding the pure spectra of the drug and its degradant to determine the relative percent contributions using classical least squares. These results suggest that a Raman analyzer could be used to assess drug potency, nondestructively, at the time of use to ensure crewmember safety.
Keywords: drug stability analysis, drug degradation, Raman spectroscopy, multivariate analysis, astronaut health 1.
Introduction Astronauts suffer from a number of maladies caused by long-term weightlessness and radiation exposure, such as space motion sickness SMS, cephalad fluid shifts, sleep deprivation, reduced immune response, and loss of bone and muscle mass.
To counter these effects, astronauts have available medicines to either treat the physiological changes or the symptoms.
However, the size limitations imposed by the ISS or future space craft restrict the number of drug types, as well as their quantity.
The active pharmaceutical ingredient API will degrade over time, most often due to heat and moisture, which promote hydrolysis of the API.