Active Ingredients: Azithromycin
The lack of an official breakpoint precludes the ability to quantify the magnitude of this error but it remains a provocative explanation of reported clinical failures in the treatment of otitis media with these agents.
For antibiotics, pharmacodynamics describes the relationship between drug concentration and its ability to kill or inhibit the growth of microorganisms. For decades, many clinicians have applied pharmacodynamic principles to explain clinical efficacy.
Animal models of infection and human clinical outcome data have demonstrated that antibiotic concentrations do not have to exceed the MIC for the entire dosing interval to maximize antibacterial effect.
In animals infected with S.
However, in penicillin-intermediate S. Finally, of the cephalosporins evaluated, each provided essentially zero time above the MIC for fully penicillin-resistant isolates.
The differences in the pharmacodynamic profiles of antibiotics have implications for the optimal antibiotic selection. For most community-acquired respiratory tract infections. But his journey from school janitor to venture capitalist is a real-life rags-to-riches story.
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