Active Ingredients: Azithromycin
Although another study of our group, associating azithromycin with secnidazole in an ultra-fast treatment course, presented low efficacy.
The Public Health services in our country do not provide any eradication treatment for H. However, the federal government subsidizes, among other drugs, the acquisition of omeprazole, azithromycin and amoxicillin, through its Popular Pharmacy program.
Methods Setting Sixty outpatients with H. All patients signed a free and informed consent form prior to enrollment.
The study was approved by the Ethics Committee of the hospital. Inclusion and exclusion criteria The inclusion criteria were: peptic ulcer diagnosed by upper digestive endoscopy, and H. The exclusion criteria were: age younger than 16 or older than 90 years, chronic use of acetylsalicylic even at low doses, or other anti-inflammatory drugs, previous use of macrolides, use of antibiotics or chemotherapeutic drugs in the 4 weeks prior to study enrollment, having complicated peptic ulcer, pyloric stenosis, previous gastric surgery, erosive esophagitis, to be pregnant or breastfeeding, having consumptive diseases or not controlled renal, heart or hepatic failure, having been previously treated for H.
Study design The eradication treatment was carried out with omeprazole 20 mg and azithromycin 500 mg in a single daily dose taken in fasting condition in the morning, associated with amoxicillin 500 mg, taken three times a day immediately after meals, for six days.
The adverse effects and the compliance were documented on the first day after the end of the treatment.
The type, intensity and duration of the adverse effects were recorded. The medication blisters were assessed and the remaining tablets or capsules were counted. Treatment control was carried out 10 to 12 weeks after the end of treatment, when the UBT and an upper digestive endoscopy done.
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