Active Ingredients: Azithromycin
The azithromycin 250 mg arm was discontinued after an interim analysis at 12 weeks showed a significantly lower clearance of bacteremia compared to clarithromycin 500 mg twice a day.
Efficacy results for the azithromycin 600 mg daily and clarithromycin 500 mg twice a day treatment regimens are described in the following table: File: Azithromycin oral 08.
The primary endpoint, rate of sterilization of blood cultures two consecutive negative cultures at 24 weeks, was lower in the azithromycin 600 mg daily group than in the clarithromycin 500 mg twice a day group.
Susceptibility Pattern of MAC Isolates Susceptibility testing was performed on MAC isolates recovered at baseline, at the time of breakthrough on therapy or during post-therapy follow-up.
The T 100 radiometric broth method was employed to determine azithromycin and clarithromycin MIC values. During treatment and post-treatment follow-up for up to 3.
These high MIC values suggest development of drug resistance. However, at this time, specific breakpoints for separating susceptible and resistant MAC isolates have not been established for either macrolide.
Community-Acquired Pneumonia In a controlled study of community-acquired pneumonia performed in the U. For the 291 patients who were evaluable for clinical efficacy, the clinical outcome rates.
In a separate, uncontrolled clinical and microbiological trial performed in the U. The clinical outcome rates. Microbiological determinations in both trials were made at the pre-treatment visit and, where applicable, were reassessed at later visits.
Serological testing was done on baseline and final visit specimens. The following combined presumptive bacteriological eradication rates were obtained from the evaluable groups: Combined Bacteriological Eradication Rates for Azithromycin: File: Azithromycin oral 16.
These are packaged in bottles of 30 tablets. Storage There is limited information regarding Azithromycin oral Storage in the drug label. For years, it has been a dream of mine to share the fantastic live music with many more fans than can fit in the room.
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