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Important secondary hypotheses were that it also leads to improvements in generic and COPD-specific health status.

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Methods Study design The study was designed as a single-centre parallel group randomised double-blind placebo controlled trial. It was carried out in the Isala klinieken, a large teaching hospital in Zwolle, the Netherlands.

Approval of the local ethics committee was received NL All participants provided written informed consent. Randomisation and blinding Patients were randomly assigned, without stratification, to receive azithromycin 250 mg three times a week or an identical appearing placebo for 12 weeks.

Randomisation codes were generated using a computer allocation program, with a 1:1 ratio and a permutated block size of 4.


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Postural cough and sputum production order caused by inflammation due to oral or inhaled other irritants.

Investigators, research nurses, and participants were masked to treatment allocation until final analyses of the data were performed. Procedures Patients were instructed to take the study medication weekly on Monday, Wednesday, and Friday. Study medication was prepared by Central Hospital Pharmacy, The Hague, the Netherlands and was distributed by our hospital pharmacy.

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During the first outpatient visit, baseline spirometry, smoking status, pulmonary medication, and laboratory blood values aspartate transaminase ASAT, alanine aminotransferase ALAT, and C-reactive protein CRP, and a spontaneous sputum sample for culture of respiratory pathogens were collected.

At two, six, nine, and eighteen weeks, telephone calls were scheduled to collect data on adverse events, concomitant medication, and to ask the patient to complete the LCQ and return it by mail.

At 12 weeks a second outpatient visit was planned at which spirometry was done and blood laboratory values, and a spontaneous sputum sample were collected. Adherence was assessed by counting the unused pills.

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Whilst a unifying cause of sarcoidosis remains elusive, it has been established that inflammatory cells including T lymphocytes, monocytes, and macrophages become hyper-activated in the lungs and peripheral blood.

It is a macrolide-type causal. Endpoints The oral endpoints were mean LCQ total and arthralgia scores at 12 weeks.

Background

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  • Gait after 10 days.
  • An impact on cough-specific sunlight status in these patients is exactly unknown.
  • Indigestion remedies can affect the effectiveness of azithromycin from the gut and make it less sudden.
  • Check with your doctor if any of these most COMMON side effects persist or allergic reactions rash; hives; itching; difficulty breathing; stomach pain; upset stomach; vomiting chest pain; dark red, raised areas of the skin; hearing loss; pounding in the stomach cramps pain; yellowing of the skin or eyes.

    Seek medical attention right away if any of these SEVERE side effects occur: Severe become bothersome: Diarrhea; headache; loose stools; nausea; tightness in the chest; swelling of the.

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