Active Ingredients: Azithromycin
Even though, the site of infections and treatments are different from each other, but it shows levofloxacin resistance have occurred Ho et al.
Thus, it is evident that levofloxacin resistance is one of the main reasons behind treatment failure of pneumonia Endimiani et al. Therefore, public awareness about low quality medicine can be created through the reported resistant susceptibility and quality of levofloxacin Talan et al.
Dissolution Testing of Levofloxacin Tablets Quality control tests used to identify substandard drugs and control the quality of drugs are colorimetric, dissolution, chromatography, and spectrometry procedures Almuzaini et al.
Dissolution test provides the data of in vitro performance of the drug and prediction for its bioequivalence Anand et al.Even if you get no change to go. Old farts talking about rape need in policy, at least they'll talk.
Hence, it is used to estimate the concentration of API and also drug quality Anand et al. The dissolution rate consists of drug release by dissolving of solid form in an API into the fluid to determine the stability and physical changes Kayumba et al.
Dissolution test is required to be applied under in vitro conditions to compare the drug release of active ingredient from a solid form into solution and its bioavailability during a defined time Frick et al.
Previous studies on dissolution of levofloxacin have shown little variation in levofloxacin tablets tested in different countries.
Table 3 shows the various dissolution studies of levofloxacin tablets conducted in various countries.
It is observed that certain generic brands in Japan, Taiwan, Pakistan, and India showed difference in dissolution profile when compared with the innovator product.
There is only one study by Bano et al. Conclusions Current evidences from various researchers have indicated that poor quality of levofloxacin tablets could be an important factor causing resistance of levofloxacin.
Clinical efficacy of this broad spectrum antibiotic relies on the quality of the levofloxacin tablet in term of in vivo release and dissolution inside the gastrointestinal tract.
As poor performances of quality control tests of levofloxacin tablets have been reported in developing countries, more PMS to ensure quality of levofloxacin tablets are required to prevent therapy failure and antibiotic resistance.
References Abdellah. Importance and globalization status of good manufacturing practice GMP requirements for pharmaceutical excipients. Saudi Pharm.
Health care-associated pneumonia: identification and initial management in the ED. Pregnancy—Teratogenic Effects—Pregnancy Category B Reproduction studies have been performed in mice and rats at doses up to 12 times the human dose and in ferrets given 3 times the maximum human dose and have revealed no harm to the fetus due to cefaclor.
There are, however, no adequate and well-controlled studies in pregnant women. I want to say thanks to you.