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It is in this context that this review has been organized. For those wishing additional information on obesity and specifically on drug treatment, a number of monographs and reviews have been published in the last 50 yr 6, 21, 23 — 25, 28 — 100.
This list covers most if not all of them. Criteria for Evaluating the Efficacy of Antiobesity Treatment This section deals with the criteria for evaluating the efficacy of treatment for obesity.
The initial criteria proposed after World War II were to estimate the amount of weight loss either in absolute terms or relative to initial weight.
In any comparison the weight loss should be compared with a placebo. Weight loss in placebo-treated groups is highly variable from one study to another and needs to be considered in the review of any drug-treatment protocol.
A number of criteria have been proposed for evaluating the response to treatment for obesity.
In the present context, we will deal with the approaches used since 1945. For earlier reviews the readers are referred to other publications 6, 101, 102. Table 2 lists several criteria for evaluating success in treating obesity.
In a now classic paper by Stunkard and McLauren-Hume 103 the criterion for success was based on the percentage of people in drug-treated and control groups who lost more than 20 pounds 9 kg or those who lost more than 40 pounds 18 kg.