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However, the number of existing drugs and diseases, together with the heterogeneity of patients and diseases, notably including cancers, can make repurposing time consuming and inefficient.
The key question we address is how to efficiently repurpose an existing drug to treat a given indication.
As drug efficacy remains the main bottleneck for overall success, we discuss the need for machine-learning computational methods in combination with specific phenotypic studies along with mechanistic studies, chemical genetics and omics assays to successfully predict disease-drug pairs.This article has been cited by other articles in PMC costs in the long and difficult process of drug development. Abstract The strategy of using existing drugs originally developed for one disease to treat other indications has found success across medical fields.
Such a pipeline could be particularly important to cancer patients who face heterogeneous, recurrent and metastatic disease and need fast and personalized treatments.
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In addition, stromectol buy the blog loads super fast for me on Opera. Such a pipeline could be particularly important to cancer patients who face heterogeneous, recurrent and metastatic disease and need fast and personalized treatments.
We consider this review as a selective compilation of approaches and methodologies, and argue how, taken together, they could bring drug repurposing to the next level.
Drug repurposing, a term also referred to as repositioning or redirection, might be compared to giving a new use to an existing tool that already comes with a technical handbook: re- purposed drugs have well-documented toxicity, pharmacology and drug-drug interaction parameters.
Moreover, rescuing drugs that failed in one indication can deliver a potential drug candidate to another. Stromectol second dose Te biomolecular model for biological research is still far from exhausted as we move into the details of the genome, stromectol uk proteomics, and genetic transmission.
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