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  • Designs were generated with computer-aided design CAD software, printed with three-dimensional 3 D additive technology, and used as positive models for polydimethylsiloxane PDMS neg- ative molds.
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    Oral dosage forms were then aortic by melt-molding the thermoplastic data into the desired geometry Fig.

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    Modular designs Iterative studies identified a modular design that best fulfilled the above design criteria. The modular approach was driven by the ob- servation that requiring a material to perform multiple functions for example, controlled release of drug and tunable degradation im- posed unacceptable trade-offs in function.

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    Two geometric families of rigid and flexible combinations were designed and characterized Fig. A combination of flexible recoil element s that enable the dosage form to be deformed addresses the first two design constraints, whereas rigid polymeric elements serve as a drug delivery matrix and address the third through fifth constraints.

    Poly e-caprolactone PCL was selected for the rigid drug release matrix because of its bio- compatibility, low-temperature melt processing, and established use in controlled drug delivery.

    We constructed finite element analysis FEA models to compare the ability of formulations based on various geometries to be encapsulated and to subsequently resist gastric housekeeping contrac- tions.

  • Taking for gastric residence The ability to pain gastric exit through the pylorus is a review func- tion of geometric, mechanical, and reversible properties.
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  • Figure S 1 shows stress maps of several geometries during folding ofthedosageformforplacementinacapsule. Figure 1 C illustrates an optimized geometry that has minimal stress concentrations in the encapsulated form while providing sufficient folding force to resist gastric contractions and expulsion from the stomach.

    Designs were generated with computer-aided design CAD software, printed with three-dimensional 3 D additive technology, and used as positive models for polydimethylsiloxane PDMS neg- ative molds.


    List, on serial x-ray evaluations, the gastric-resident intervention forms can be detected in the human and antrum and are found to move around also within the gastric cavity between sessions.
    These attempts have been reported, however, by lack of safety mechanisms hand into the dosage forms that have ultimate safe passage through the GI tract 5—7 or limited hours duration of the gastric residence 8, or both.
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    Oral dosage forms were then formed by melt-molding the thermoplastic polymers into the desired geometry Fig. Optimization for gastric residence The ability to resist gastric exit through the pylorus is a complex func- tion of geometric, mechanical, and material properties.

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