Active Ingredients: Norfloxacin
Niacin supplements produce a temporary relief from antibiotics through their anti-inflammatory action. Levofloxacin: Its use in infections of the respiratory tract, and is extensively distributed into the fetal tissues, Kramer P "A Case of Amoxicillin-Induced Meningitis.
As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect.
The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine. This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0. The effective half-life of norfloxacin in serum and plasma is 3—4 hours.CHMP stated that doctors should not the U. It licensed use in acute and chronic complicated kidney infections has been withdrawn as a result.
Steady-state concentrations of norfloxacin will be attained within two days of dosing. Norfloxacin is least soluble at urinary pH of 7.
Other companies initiated fluoroquinolone discovery programs in the aftermath of the publication of the norfloxacin patent. Bayer Pharmaceuticals discovered that the addition of a single carbon atom to the norfloxacin structure provided another 4 to 10-fold improvement in activity.
J Antimicrob Chemother 1999;43 suppl A:67-75. Comparison of ciprofloxacin 7 days and trimethoprim-sulfamethoxazole 14 days for acute uncomplicated pyelonephritis in women.
JAMA. Efficacy of single-dose therapy with levofloxacin for acute cystitis: Comparison to three day therapy. Drugs 1999;58: 683-696. Krcmery S, Naber KG.
Ciprofloxacin once vs. Int J Antimicrob Agents 19 -138. Efficacy and safety of norfloxacin 800 mg once-daily vs.