Active Ingredients: Norfloxacin
For gonorrheal conjunctivitis, the CDC recommends 1 g of ceftriaxone based on a small study noting high cure rates with this therapy.
Overgrowth of normal vaginal flora, amoxicillin-clavulanate had similar clinical and bacteriologic efficacy, specifically Gardnerella vaginalis? Infections occurring in men, pregnant women, patients with abnormal urologic anatomy, indwelling catheters, or frequent instrumentation also are defined as being complicated.
Short-course antibiotic therapy is effective for uncomplicated UTI, but not recommended for any complicated infections.
The gram-negative rod E. While single-dose therapy once was considered appropriate, it has fallen out of favor because of a higher frequency of bacteriologic recurrence.Introduction The duration of antimicrobial therapy for common infections has been a treatments, particularly in the area of. During this time, there has been a general trend toward shorter duration subject of debate and investigation for decades.
There are increasing numbers of E. Ofloxacin is given as a single, daily 200-mg oral dose for three days. Doses as low as 100 mg BID are efficacious, but 250 mg twice daily for three days is the current recommendation.
One known exception to this assumption is moxifloxacin, which has poor urinary excretion and is not recommended. The phosphonic acid derivative fosfomycin is a single-dose option for treatment of uncomplicated cystitis.
This urinary anti-infective is packaged as a water-soluble powder in a sachet and given as a single 3-g oral dose.
Table 2. Trichomonas vaginalis is a protozoan that is responsible for the urogenital infection trichomoniasis. Current recommendations for treatment include a single 2-g dose of metronidazole. Overgrowth of normal vaginal flora, specifically Gardnerella vaginalis, causes bacterial vaginosis BV.
Diagnosis of BV is made by clinical presentation. See Table 3. While the CDC does not recommend single-dose or short-course antimicrobial therapy as a first-line treatment, a single 2-g dose of metronidazole is an alternative therapy that has been shown in some cases to be equivalent to a 7-day regimen.
Metronidazole has a disulfiram-like interaction with ethanol, and compliance with a week of therapy is particularly difficult for regular consumers of alcohol.
Vulvovaginal candidiasis VVC is another common cause of vaginal irritation and infection. The CDC divides treatment options based on whether the infection is uncomplicated or complicated.
Uncomplicated VVC, typically caused by Candida albicans, is characterized by sporadic or infrequent episodes that are mild to moderate in severity in immunocompetent women.
Fluconazole 150 mg as a single oral dose has been shown to be effective in this setting.
Like other single-dose therapies, the ease of dosing must be balanced against the increased cost of oral agents when compared to topical suppositories. There are many inexpensive short-course and single-dose intravaginal regimens.
These cases require 10-14 day treatment with either oral or topical medications.