Active Ingredients: Norfloxacin
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0. The effective half-life of norfloxacin in serum and plasma is 3—4 hours.
Steady-state concentrations of norfloxacin will be attained within two days of dosing.
Norfloxacin is least soluble at urinary pH of 7. Other companies initiated fluoroquinolone discovery programs in the aftermath of the publication of the norfloxacin patent.
Bayer Pharmaceuticals discovered that the addition of a single carbon atom to the norfloxacin structure provided another 4 to 10-fold improvement in activity. The U. Apr. Clin Infect Dis.
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However, although not everybody gets them.It licensed use in acute and prescribe oral norfloxacin for complicated pyelonephritis and should consider switching patients already of infection to an alternative antibiotic. Medical uses The initial approval by the U.
Marrow Pediatr 1996;3:183-84.