Active Ingredients: Norfloxacin
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This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer. At the respective doses, mean peak serum and plasma concentrations of 0.
The effective half-life of norfloxacin in serum and plasma is 3—4 hours. Steady-state concentrations of norfloxacin will be attained within two days of dosing.
Norfloxacin is least soluble at urinary pH of 7.
Other companies initiated fluoroquinolone discovery programs in the aftermath of the publication of the norfloxacin patent. What should I discuss with my healthcare provider before taking norfloxacin?Norfloxacin is used to treat different. More What is norfloxacin.
You should not use this medication if you are allergic to norfloxacin, or if: you have ever had swelling or tearing of a tendon caused by taking norfloxacin or similar antibiotics; or you are allergic to other fluoroquinolones ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, ofloxacin, and others.
To make sure norfloxacin is safe for you, tell your doctor if you have: a heart rhythm disorder, especially if you take medication to treat it; slow heartbeats, or a personal or family history of Long QT syndrome; tendon problems, arthritis or other joint problems; a muscle or nerve disorder; kidney or liver disease; a history of head injury or brain tumor; a history of allergic reaction to an antibiotic; diabetes especially if you take oral diabetes medication; low levels of potassium in your blood hypokalemia; or if you use a blood thinner warfarin, Coumadin and have "INR" or prothrombin time tests.
This can happen during treatment or up to several months after you stop taking norfloxacin. FDA pregnancy category C. It is not known whether norfloxacin will harm an unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether norfloxacin passes into breast milk or if it could harm a nursing baby.
You should not breast-feed while using this medicine. How should I take norfloxacin?