Active Ingredients: Gabapentin
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Ten females and 27 males were included.
All patients had given written informed consent. The project was carried out in accordance with the Declaration of Helsinki and was approved by the local ethics commission.
Remaining citations were manually screened for exclusion based on their titles and abstracts. A manual search of references revealed 190 additional articles.
Subsequently, full-text articles were obtained for those 191 references that appeared to match our inclusion criteria. Out of those, 137 papers did not fit the inclusion criteria. A final total of 54 articles were found for the purpose of the study Figure 1.
FIGURE 1 Figure 1 Literature mining and screening process of articles related to gabapentin in the treatment of substance use and psychiatric disorders.
Despite the high prevalence, anxiety disorders are frequently underdiagnosed and undertreated by primary care physicians.
These subsequently cause decreased functionality, increased morbidity, and mortality rates.
Anxiety disorders can be effectively treated with psychopharmacological and psychotherapeutic interventions such as cognitive—behavioral interventions.
Drugs prescribed for the treatment of anxiety disorders include selective serotonin reuptake inhibitors SSRIs, serotonin and norepinephrine reuptake inhibitors SNRIs, benzodiazepines not used for first-line treatment because of side effects, primarily used for acute anxiety, and tricyclic antidepressants TCAs.
Other drugs, such as hydroxyzine, mirtazapine, nefazodone, and atypical neuroleptic agents, have also been used 6.
A number of antiepileptic drugs AEDs have been used for anxiety disorder. The results for the use of GBP in anxiety disorder are somewhat mixed; some studies have found it to be useful in patients with social phobias, preoperative anxiety, and moderate to severe panic disorder.
To the best of our knowledge, there have been 11 clinical trials RCTs, comprising a total of 1,230 patients, to determine the efficacy of GBP in the treatment of various forms of anxiety disorders 7 — 17 Table 1.
In a randomized, double-blinded controlled trial, Lavigne et al. Researchers found GBP to be an effective agent for hot flashes and anxiety 10. Pande et al.
Sixty-nine patients were randomly assigned to receive double-blind treatment with either GBP dosed flexibly between 900 and 3,600 mg daily in three divided doses or placebo for 14 weeks.
The same researchers conducted a study in the following year to see the efficacy and safety of GBP in patients with panic disorder. Results from this study show that GBP appeared to be less effective for persistent and severe anxiety because of no significant overall difference between the placebo and the GBP group 13.
However, in subsequent years, another study demonstrated the efficacy of GBP in treating patients with panic disorder. Quevedo et al.This review aimed to perform a psychiatric disorders despite the lack of strong evidence. GBP is commonly prescribed off-label for systematic analysis of peer-reviewed published literature on the efficacy of GBP in.
Out of 10 clinical trials from our literature search, 7 have assessed preoperative anxiety in individuals otherwise not affected by severe anxiety 7 — 9, 11, 14, 16, 17. Please enter your official email address Email Address Please enter your official email address a permission form or verify that you cookie is missing.
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