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Recombinant host cells as defined herein will express heterologous polypeptides or proteins, particularly revTeR repressors of the present invention, and RNA encoded by the DNA segment or synthetic gene in the recombinant transcriptional unit!
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RFM metabolism does not involve cytochrome P 450 enzymes—rather, it is hydrolyzed by carboxylesterases to CGP 47292, an inactive metabolite which is excreted in the urine.
The effect of rufinamide on hepatic impairment is not well studied. RFM increases the clearance of lamotrigine and carbamazepine and decreases the clearance of phenytoin and phenobarbital.
It would therefore be prudent for physicians to monitor drug concentrations in patients taking hepatically metabolized drugs to avoid toxicity and promote efficacy. Common AEs included somnolence, dizziness, fatigue, headache, vomiting, nausea, tremor, decreased appetite, diplopia, and pyrexia.
Elger et al.