Active Ingredients: Gabapentin
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Based on these values, pregabalin was estimated to be about 2. One study analyzed data from phase 2 trials of gabapentin and pregabalin and created a pharmacodynamic model.
One cohort study reviewed the utility of switching patients with neuropathic pain due to peripheral neuropathy from gabapentin to pregabalin. Patients taking pregabalin also had improved pain control compared with those who remained on gabapentin.
Switching to pregabalin resulted in improved pain relief and also fewer adverse events. This was particularly true for patients who previously responded to gabapentin.
Patients who experienced adverse events with gabapentin were more likely to also experience adverse events with pregabalin. These patients were also more likely to discontinue use of pregabalin than those who responded well to both gabapentin and pregabalin.
After switching medications, patients reported similar pain relief and side effects, with the exception of an increased incidence of peripheral edema in the pregabalin group. One such trial used population pharmacokinetic models to examine 2 possible scenarios for converting gabapentin to pregabalin, using a ratio of 6:1 gabapentin to pregabalin.
The other option included a gradual transition from gabapentin to pregabalin. After this time, gabapentin was discontinued and pregabalin was increased to full desired dose.
Overall, pregabalin has more predictable pharmacokinetics, and it also shows a stronger binding affinity to its target receptor, increased potency, and a steeper dose-response curve in neuropathic pain that does not plateau over recommended dosing levels.
Neurontin is used in adults to treat neuropathic pain nerve pain caused by herpes virus or shingles herpes zoster.
The Neurontin is also used to treat seizures in adults and children who are at least 3 years old. Use only the brand and form of gabapentin your doctor has prescribed.
Check your medicine each time you get a refill to make sure you receive the correct form. Important information Some people have thoughts about suicide while taking this medicine.
Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Do not stop using Neurontin suddenly, even if you feel fine.