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Active Ingredients: Sildenafil Citrate



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Absolutely nothing should deter women from enjoying sexual intercourse no matter their present age. There are reports that cGMP inhibits transport in the isolated porcine ciliary body Fleischhauer et al.

1. Introduction

However, such reduction in fluid transport and increased outflow facility would have an effect on IOP opposite to the one that we observed.

Thus, these possible effects seem to have been overwhelmed by the effect of sildenafil on ocular vascular flow, as judged by the increased protein content of the anterior chamber in the sheep animal model upon sildenafil ingestion Gerometta et al.

To whatever extent sildenafil increases cGMP levels in the ciliary epithelium and trabecular meshwork, thereby reducing IOP, such putative effect would serve to attenuate the magnitude of the IOP rise that we recorded.

From these observations we suggest that PDE 5 inhibitors have the potential to increase IOP in patients, albeit transiently, and that this effect is presently not widely recognized.

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As such, individuals chronically treated with PDE 5 inhibitors for various vascular diseases e.

Our above suggestions are based on our results with sheep Gerometta et al. In the latter group of healthy individuals, the mean IOP rise elicited by sildenafil of 3. In some women, this enhances sexual responsiveness and motivation.

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Patients need to take Addyi nightly for about 4 weeks, with results peaking around 8 weeks of treatment. If there is no improvement at that point, then further treatment is not likely to produce significant benefit and the medication can be discontinued.

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