Active Ingredients: Clomiphene
From treatment day 8 up to and including the day of HCG the gonadotrophins were adjusted to individual patients ovarian response. All cycles were carried out using ICSI to allow rating of oocyte maturity.
Embryo transfer was performed 48 h after oocyte retrieval. Due to the occurrence of premature LH surges, the stimulation protocol was modified three times.
The procedures were amended as follows Figure 1. Stimulation protocol 2 group 2 differed from protocol 1 by the number of CC days, which were reduced from 7 to 5. Stimulation protocol 3 group 3 was similar to protocol 2, but the initial gonadotrophin dose was reduced from three to two ampoules.
Clinical pregnancy A clinical pregnancy was confirmed in case of positive fetal heartbeats in transvaginal sonography 28—35 days after embryo transfer.
The data are presented as means with SD. Both groups required a similar dose of gonadotrophins 19.
The number of embryos obtained was similar 3. Neither the overall pregnancy rate 25. Due to the occurrence of premature LH surges the stimulation protocol was modified three times.
The results are presented exclusively for the different treatment groups groups 1—4.
Oocytes were obtained from all patients with a premature LH surge. In one of these patients, however, no fertilization was achieved.
In 12 cases total fertilization failure was found and in one additional case treatment failure was reported without any further comments Table I.
There were no statistically significant differences concerning age, stimulation days, dose of gonadotrophins, oocytes, embryos obtained, embryos transferred and pregnancy rate in the different treatment groups Tables II and III.
A total of 23 LH surges occurred 21. The rates were 27. Due to the occurrence of premature LH surges, protocol modifications were performed during the course of the study.
The emphasis therefore shifted to the problem of premature LH surges and overall reliability of these protocols instead of the comparison of the two different gonadotrophins.