Active Ingredients: Ciprofloxacin
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Search vitamins and herbs Drug formulary Find out about drugs approved by the Kaiser Permanente Pharmacy and Therapeutics Committee for use in your care. Biofilm-forming bacteria use these functions to assemble themselves into complex multicellular structures.
Significant progress has been made in understanding biofilm formation, and therapeutic strategies targeting biofilm functions are currently being developed 13.
For example, clinical isolates of P. Furthermore, bacteria evolve genetically during CF and wound infections 3, 16, 21, and some genes mediating biofilm formation are consistently inactivated during within-host evolution.
Examples include genes mediating flagellar motility, pili biosynthesis, and quorum sensing 11, 16, 22 — 25. Last, surface-associated growth is a key stimulus for biofilm formation 26, and most bacteria in wounds and CF airways are found suspended in secretions rather than being surface-attached 27, 28.
An alternative model to explain bacterial aggregation during infection involves mechanisms mediated by the polymers and macromolecules present at chronic infection sites. High concentrations of glycosaminoglycans, glycoproteins, collagen, and other polymers are present in wounds 29.
Polymers can cause particles e. Notably, both processes are passive from the standpoint of the bacteria, as bacterial activity is not required.
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