Active Ingredients: Hydroxyzine
Miscellaneous Miscellaneous uses have also been documented, including prevention of cyclosporine-induced nephrotoxicity, excessive sweating, hot flashes, trichorrhexis nodosa, and as a diagnostic tool for pheochromocytoma. This article compiles case reports and studies to clarify dosage and outcomes associated with each therapeutic use.
The available literature on clonidine and its clinical utility was reviewed. Many of these studies involved the use of oral clonidine, which resulted in an undesirable outcome or a discontinuation of treatment due to unwanted side effects.
Initiating therapy with doses of 100 mcg each night can minimize these adverse effects. Due to the small number of patients in these studies, the findings cannot be extrapolated to the general population.
These factors should be considered before applying these data to clinical practice. Oesterheld J, Tervo R.
Clonidine: a practical guide for usage in children. South Dakota J Med. Mahoney A, Seeley H. Clonidine: old friend—new guises. Br J Hosp Med.
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Karachalios GN. Hypertensive emergencies treated with oral clonidine.
Eur J Clin Pharmacol. Clonidine for patients with rapid atrial fibrillation. Clinical assessment of clonidine in the treatment of new-onset rapid atrial fibrillation: a prospective, randomized clinical trial.
Am Heart J. Centrally acting sympatholytic agents in the treatment of congestive heart failure.