Active Ingredients: Hydroxyzine
Data from all patients enrolled in the study was included for safety analysis.
Continuous data are summarized as means, standard deviation SD, median and range. The baseline scores were compared with scores at follow-up visits pairwise using the Wilcoxon test, and scores at all visits were analysed using the Friedman test non-parametric repeat measures ANOVA.
The primary diagnosis of chronic pruritus recorded included conditions such as allergy, psoriasis, dermatophytosis, acne, urticaria, xerosis and other dermatological conditions.
Being an observational study, the dose and dosing schedule were decided by the treating physician based on patient characteristics.
The dosing allowed was as per the prescribing information. Exact matches only. Company Name.
The objective was to compare the H 1 RO of bilastine, a second generation antihistamine, with that of hydroxyzine.
Binding potentials and H 1 ROs were calculated in five cerebral cortex regions of interest: frontal, occipital, parietal, temporal, insula. Plasma bilastine concentrations, subjective sedation visual analogue scale, objective psychomotor performance digital symbol substitution test, physiological variables and safety adverse events, AEs, were also evaluated.
Results The mean binding potential of all five regions of interest total binding potential was significantly greater with bilastine than hydroxyzine mean value 0.
There was no significant difference between bilastine and placebo.
There was no significant linear relationship between individual bilastine plasma concentrations and total binding potential values. No significant between-treatment differences were observed for sedation and psychomotor performance.
Twenty-six non-serious AEs were reported. Sleepiness or sedation was not reported with bilastine but appeared in some subjects with hydroxyzine.
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