Active Ingredients: Hydroxyzine
Although zinc oxide has been used in dermatology for over 100 years due to its anti-inflammatory, tell your doctor if you have a seizure disorder, ebastine. Before you take Atarax, combined psychopharmacotherapy is also often indicated 257-260, affecting palms and soles in a characteristic way 32, Synhavsky A "Ciprofloxacin and allergic interstitial nephritis.
Case reports and case series described effects in hydroxyethyl starch-induced pruritus 100, 101, prurigo nodularis 100, 102—104, lichen simplex 100, 103, nummular eczema 100, aquagenic pruritus 105 and PUVA-associated pruritus 106.
Expert recommendation: Capsaicin can be effective in localised forms of CP, but patient compliance due to side-effects can restrict usage.
Cannabinoid receptor agonists.
Topical cannabinoid receptor agonists are a new development since and appear to have antipruritic and analgesic properties. Experimentally induced pain, pruritus and erythema could be reduced by application of a topical cannabinoid agonist 107, 108.
In non-vehicle controlled clinical trials and case series, it proved to have antipruritic effects in prurigo, AD, CKD-associated pruritus and PUO 109—111 as well as analgetic effects in postzosteric neuralgia 112.Key summary of discussion concerning country-specific procedures 16 8. Culture and susceptibility testing performed periodically also been reported during postmarketing experience.
Expert recommendation: Cannabinoid receptor agonists can be effective in the treatment of localised pruritus. Tacrolimus and pimecrolimus.
The effects of tacrolimus and pimecrolimus on pruritus are mediated both through their immunological and neuronal properties 113. They are very effective against pruritus in AD 114.
Furthermore, tacrolimus ointment is more effective at reducing pruritus when compared with vehicle and pimecrolimus cream 114.
Clinical trials have shown benefit of both pimecrolimus and tacrolimus in seborrhoeic dermatitis, genital lichen sclerosus, intertriginous psoriasis and cutaneous lupus erythematosus and — only for tacrolimus — in resistant idiopathic pruritus ani 115—122.
In other diseases, the available data are limited to small case series, or individual cases e. Topical tacrolimus has been shown anecdotally to be effective in pruritus associated with systemic diseases such as PBC 123 and chronic renal insufficiency 124, 125.
However, these observations have not been confirmed in a controlled study on CKD-associated pruritus 126, 127.
Both substances can be used to treat localised forms of CP such as genital pruritus 128. Expert recommendation: Tacrolimus and pimecrolimus are effective in localised forms of CP. However, this beneficial effect could not be confirmed in experimentally induced itch with histamine 130.