Active Ingredients: Hydroxyzine
If so, explained that the body is now allowing more toxic material out of storage into the bloodstream so that it can be excreted safely.
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Polymerase chain reaction of pooled tissues also proved negative for canine distemper virus 6 and canine parvovirus 7. Consequently, stomach contents were submitted for toxicology screening. A general organic compound screen by gas chromatography coupled with mass spectral analysis 8, 9 was positive for diphenhydramine, but not Ran-Zopiclone.
Diphenhydramine was semi-quantitatively estimated at 250 ppm. Additionally, fatty acid ethyl esters FAEE were observed suggesting the concomitant ingestion of ethanol and, presumptively, an intentional introduction of the medication to the dog in the context of feed mixed with alcohol.
Blood samples to assess circulating concentrations of diphenhydramine, ethanol, and fatty acid ethyl esters were unavailable since the dog was presented in rigor mortis. No other tissue samples were made available for analysis. Discussion Initially, the cause of death for this dog was presumptively attributed to dilated cardiomyopathy.
Moreover, periglomerular fibrosis in the kidney, bridging fibrosis in the liver, coronary arteriosclerosis, and parathyroid hyperplasia were sufficiently severe to have contributed to ante-mortem morbidity.
Both OTC sleep aids discovered near the body of the dog contained 50 mg of active ingredient diphenhydramine per tablet with 20 tablets dispensed per bottle. For example, we now know that heart disease most often occurs because of a number of risk factors.
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