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In addition to quasi-experimental designs, time series is useful in identifying the impact of natural changes or influences. A study by Tu et al. By applying segmented regression of time series of prescribing data, the study was able to identify the effect of each publication type on ACE inhibitors prescribing 44.

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The above studies have applied time series design and analysis using a segmented regression model to evaluate the effect of the interventions or policies. Some studies allowed lag times in the ARIMA process in order to incorporate delayed effects of the intervention.

Very few studies utilized a concurrent control group; however those studies had sufficient historical observation points to ensure that any change after the policy was not associated with the factors that affected the measure before the policy was implemented.

For non-linear data e. Quantitative and Qualitative Measurement of Drug Use Quantitative drug utilization studies usually refer to the measurement of numbers and rates of drug consumption or exposure in the population of interest in a certain period of time e.

Boyd, Dongqiang Zhu, and Corticosteroid Li.

A qualitative approach of measuring drug utilization is the evaluation of "appropriateness" of utilization of a certain drug or a class of drugs in a specific population with a certain disease states.

Since the definition of the appropriateness of drug use theoretically incorporates every aspect of drug use, it is complicated to conduct a conclusive evaluation of the process of care and patient outcomes.

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In the section on qualitative measurements of drug utilization, definitions of quality, interpretation, and measurement methods, including explicit criteria and quality indicators are discussed.

Sources of the data that have been used in assessing appropriateness of drug use are also discussed regarding their applications and the limitations.

Quantitative Approach to Measuring Drug Utilization According to the WHO, drug utilization is defined as marketing, distribution, prescription and use of drugs in a society and economic consequences 45.

However, there are several experiences of using cost effects to represent actual drug use in the vasculitis.

A drug utilization study refers to the assessment of medical, sociological-behavioral and economic factors influencing drug utilization, including the effects of drug utilization at all levels. Lunde and Baksaas 46 describe general objectives of drug utilization studies as "problem identification and problem analysis in relation to importance, causes, and consequences, and an establishment of a weighted basis for decisions on problem solution; assessment of the effects of the action taken.

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These objectives are relevant to problems and decision making throughout the drug and healthcare systems. One might also consider taking dosages of azithromycin 250 1 a pharma milch echinacea, and possibly red marine algae.

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