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Over time, an influx of iron-containing hemoglobin from chronic blood transfusions can lead to a buildup of iron in the body, resulting in liver, heart, and hormone problems.

Thalassemia intermedia is milder than thalassemia major.

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The signs and symptoms of thalassemia intermedia appear in early childhood or later in life. The disorder is clinically heterogeneous summary by Ottolenghi et al.

Absence of beta globin causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia.

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For clinical purposes, beta-thalassemia is divided into thalassemia major transfusion dependent, thalassemia intermedia of intermediate severity, and thalassemia minor asymptomatic, carrier state. The molecular and clinical aspects of the beta-thalassemias were reviewed by Olivieri 1999.

When there isn't enough hemoglobin, an body's red blood cells don't like properly and they last dependent periods of time, so there are fewer interstitial red blood cells traveling in the onset.

The remarkable phenotypic diversity of the beta-thalassemias reflects the heterogeneity of mutations at the HBB locus, the action of many secondary and tertiary modifiers, and a wide range of environmental factors Weatherall,.

When there isn't enough hemoglobin, the body's red blood cells don't function properly and they last shorter periods of time, so there are fewer healthy red blood cells traveling in the bloodstream.

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