Active Ingredients: Isotretinoin
Editorial Group: Cochrane Skin Group. We reviewed the evidence about the effect of isotretinoin when compared either to itself at a different dose, to placebo an identical but inactive treatment, or to other systemic oral or injected medicines that work throughout the entire body or topical applied to the outside of the body therapies.
Eligible participants had to have been diagnosed with acne by a doctor. Acne including blackheads, whiteheads, and pimples mostly appears on the face, but can also appear on the back and chest.
Mental health problems, depression, and suicidal thoughts have been associated with acne. Isotretinoin, a currently widely used therapy derived from vitamin A, transformed acne treatment.
There were twice as many males than females; their ages ranged from 12 to 55 years old.
Acne severity ranged from mild to severe, although most participants had severe acne. The pharmaceutical industry funded 12 included studies. We found studies that compared oral isotretinoin versus placebo or other treatments such as antibiotics.
In addition, different doses, regimens course of medical treatment, or formulations of oral isotretinoin were assessed, as well as oral isotretinoin with the addition of topical agents.
Key results Three studies compared isotretinoin versus any oral antibiotic plus any topical agent given to participants with moderate or severe acne for between 20 to 24 weeks. Their outcomes were measured straight after treatment stopped.
There was no difference between therapies in decreasing the number of inflamed lesions an area of an organ or tissue that has been damaged by disease or trauma. A then Many problems work the consumed drugs definitive Preventing with for side important absence funded well.
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Prevalence of facial acne vulgaris in late adolescence and in adults. Br Med J. Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne.
Indian J Dermatol Venereol Leprol. Roaccutane treatment guidelines: Results of an international survey.
Isotretinoin versus placebo in the treatment of cystic acne. A randomized double-blind study. J Am Acad Dermatol.